Best Ideas 2020 features all the nominated entries submitted under ‘Submit your Idea’ category. All the entries consist of innovative solutions or propositions for an enterprise that champions the Sustainable Development Goals. They can be on the conceptual, planning, or start-up stage.
Potential of Indonesian plants for the prevention of Corona Virus infection
Explain your idea in details:
Some Indonesian plants contain potentially active compounds as agents to inhibit the infection or replication of SARS-CoV-2 based on their activities on relevant therapeutic targets. These potentially active compounds are compounds contained in Indonesian plants at least have activity on the targeted therapy in vitro level. Some Indonesian plants and their compounds that have the potential to be developed in the prevention of COVID-19 are plants that have the potential to slow down the interaction of ACE2 receptors with proteins. Currently, ACE2 is a receptor that was successfully identified as the entry of SARS-CoV-2 virus in infecting humans. The ACE2 receptor is widely expressed in the lungs (especially endothelial lung cells). The Virus begins its infectious process by involving the interaction between the S proteins in SARS-CoV-2 with ACE2 on the host cell. The risk of infection can be prevented or reduced by plant compounds that are able to interfere with such interactions. Some Indonesian plants contain compounds that have the potential to prevent or reduce this viral infection. An example is an Emodin and luteolin compound that prevents the interaction between the ACE2 receptors and the S proteins in SARS-CoV. Indonesian plants that contain a lot of Emodin, among others, Aloe aloe (Aloe vera; leaf), Weakness (Rheum officinnale; root), and in the seeds of a genus of Cassia, such as Cassia alata or Senna alata (Ketepeng kebo), Cassia obtusifolia or Senna obtusifolia (Javanese beans), and Senna Alexandrina While many plants contain luteolin, among others celery (Apium graveolens, leaves and seeds), Tread Liman (Elephantopus scaber; leaves and flowers), onions (alium cepa; leaf), Broccoli (Brassica oleracea), green chilies (capsispring annuum; fruit), belimbing wuluh (Averrhoa bilimbi; leaf and fruit), citrus kaffir lime (citrus hystrix; leaf), and carrot (Daucus carota; tuber).
Expected impact of your idea on sustainable development
SARS-CoV-2 infections in humans other than the need of ACE2 receptors as entrances, also involve S proteins on the surface of viruses to bind to the ACE2 receptors. At a later stage, the activity of Serin protease enzyme is required by TMPRSS2 (a transmembrane glycoprotein) which allows the virus to melt and enter the target cell to initiate its infection. Inhibition of Serin protease activity is a target in the prevention of viral infections. Recent research from a reputable journal Cell published that in addition to the attachment of embedding with ACE2 receptors, inhibition of protease enzymes (especially serine proteases) is also a potential target for controlling this latest Korona virus infection. Compounds that inhibit protease on serin residues (serine protease inhibitors, hereinafter referred to as SPI) are expected to be good drug candidates for stopping the viral life cycle. Plant-derived SPI compounds are generally proteins or molecules containing proteins (large molecules). Legume family Plants (Fabaceae, Poaceae, and Solanaceae) are the main sources of SPI producing the plant. The protein fraction derived from the seeds of legumes is rich in the compound SPI. Examples of legumes that are seeds containing SPI are peanuts (Arachis hypogaea), soybeans (Glycine max), chickpeas (Phaseolus vulgaris), Capri (Pisum sativum), and snagged (Crotalaria juncea). All the compounds and plants mentioned in this paper to date have not been tested its effectiveness in the experimental models relevant to SARS-CoV-2 because this virus was newly identified in the early 2020. However, these crops have the potential as an infection prevention or the development of SARS-CoV-2 based on the therapeutic targets in the COVID-19 that have been identified and based on their activities against SARS-CoV. The idea is to review several potential Indonesian plants to be researched and developed further as an anti SARS-CoV-2 agent.
Plans for implementation and sustainability
It is currently being developed as a silico technique for predicting plant compounds that can be used to prevent the infection and replication of SARS-CoV-2 by predicting its interactions with targets in this disease. Examples are flavonoids methoxy compounds such as hesperetin, Tangerine, Naringenin, and nobiletin on oranges (Citrus sp.; fruit and skin), and a baikalin compound, Skutellarin, Glysirizin, Rhoifolin, Herbasetin, Pectolinarin and Galangin on galangal (Alpinia galanga; rhizome). However, predictions based on this computing model still requires proof of laboratory testing. There are many strategies that are currently being developed by researchers in search of active antiviral compounds including those derived from natural ingredients compounds sourced from plants. The high biodiversity of Indonesian plants provides a diversity of natural substance compound structure that is also a major capital in the efforts of drug discovery, including drugs for diseases caused by SARS-CoV-2. It is also a challenge for World researchers and Indonesian researchers.
I am 25 years old. I was born in Jayapura, October 26, 1994. Starting my experience in the field of OSIS (Intra School students organization) in junior high school as the head of Division and entered in the field of Scout, I am an expert in the field of analyzing and breaking the password. When I was in high school I majored in Science and I was interested in scientific writing in the field of science such as abstract, paper, journal, and Research. Until attending college I took a degree in mathematics education at the University of Darussalam Ambon. During my college I was active in several organizations such as BEM, HIMAMPRO, and KAMMI. In addition I have experience to be an assistant Lecturer and laboratory assistant on the courses of general biology, environmental knowledge, electronics and electrical magnets. My thesis is on the undergraduate lecture on the content/compounds contained in water used by residents living in slums. I have been working as a Data Operator and lecturer at STIKOM Ambon Campus for 2 years. I've participated in the "technical guidance of university operators " organized by LLDIKTI XII in 2018 and training on Python for Data Science in Cognitive Class in 2020. When COVID-19 entered Indonesia I began to be active as a volunteer at MRI (Indonesia Volunteer Society)/ACT Maluku Branch by joining the program of work including spraying liquids in community houses, division of masks to the community, distribution of food iftar for daily workers during Ramadan, and the distribution of food in the form of rice to communities in need.